Pulmonary Surfactant Protein A (SP-A): Essential Regulator of Lung Homeostasis and Innate Immunity
Endocrinology Diagnostics
Key Summary of Pulmonary Surfactant Protein A (SP-A):
Molecular Structure
- Collectin protein family member
- Two gene variants (SP-AI and SP-A2)
- Octadecameric bouquet-like structure
Lung Surfactant Functions
- Reduces surface tension
- Prevents alveoli collapse
- Manages surfactant balance
- Supports air sac stability
Immunomodulatory Properties
- Recognizes pathogen-associated patterns
- Enhances pathogen clearance
- Regulates immune cell activities
- Controls inflammatory responses
Pathological Implications
- Critical in respiratory distress syndrome
- Impacts lung infection responses
- Associated with asthma and COPD
- Genetic variations linked to respiratory diseases
Biosynthesis
- Produced in alveolar type II and Club cells
- Regulated by developmental and inflammatory factors
- Involves post-translational modifications
Suitable ELISA Kits
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