Understanding FGF23: Role, Mechanisms, and Clinical Implications
Endocrinology Diagnostics
Key Points about FGF23:
Protein Characteristics
- Fibroblast growth factor family member
- Produced by bone osteocytes and osteoblasts
- Regulates phosphate and calcium balance
Mechanism of Action
- Binds to receptors in kidneys and parathyroid glands
- Promotes phosphate excretion
- Reduces vitamin D production
- Suppresses PTH levels
Physiological Role
- Maintains phosphate homeostasis
- Prevents phosphate overload
Clinical Implications
- Chronic Kidney Disease
- X-Linked Hypophosphatemia
- Tumor-Induced Osteomalacia
- Cardiovascular Disease
- Genetic disorders
Potential Therapeutic Targets
- Modulating FGF23 activity
- Managing phosphate metabolism
- Mitigating adverse effects in kidney diseases
Key Functions
- Phosphaturia
- Inhibiting phosphate reabsorption
- Regulating vitamin D synthesis
FGF23 is a critical hormone in maintaining mineral balance and metabolism, with significant implications for kidney and bone health.
Suitable ELISA Kits
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